Question 1

Marginal-zone B cells express

Accepted Answer

A)  IgD.
B)  IgG.
C)  IgM.
D)  IgE.
E)  Both IgG and IgM are correct.F) A) and C)
G) A) and B)

Question 2

Of the cells listed below, which one represents the MOST developed B cell?

Accepted Answer

A)  Pre-pro-B cell
B)  Pro-B cell
C)  Pre-B cell
D)  T1 B cells
E)  T2 B cellsF) B) and C)
G) B) and D)

Question 3

What is the initial location of B-cell and T-cell development?

Accepted Answer

A)  Blood for B cell and thymus for T cell
B)  Bone marrow for both B cell and T cell
C)  Bone marrow for B cell and thymus for T cell
D)  Secondary lymphoid organs for B cell and thymus for T cell
E)  Thymus for both B cell and T cellF) C) and D)
G) A) and B)

Question 4

Individuals of retirement age or older show lower antibody mediate immune responses due to all the following reasons EXCEPT

Accepted Answer

A)  increased likelihood of autoimmune disorders.
B)  limited HSC production of pro-B cells.
C)  poor antibody response to vaccination.
D)  reduced-memory B-cell generation.
E)  smaller thymus.F) A) and B)
G) B) and C)

Question 5

All of the following are true regarding B-cell development EXCEPT

Accepted Answer

A)  B cells complete maturation in the spleen.
B)  B cells are mostly developed when they leave the bone marrow.
C)  B cells, like T cells, are MHC class restricted.
D)  Self-reactive B cells may be eliminated though apoptosis.
E)  Self-reactive B cells may be rendered unreactive (anergic) .F) B) and D)
G) A) and B)

Question 6

Hematopoiesis begins at around day 7 after fertilization in mice.What is the site of precursor cells at this stage of fetal development?

Accepted Answer

A)  Bone marrow
B)  Fetal liver
C)  Placenta
D)  Primitive organ
E)  Yolk sacF) All of the above
G) C) and D)

Question 7

Mature naïve B cells express high levels of _____ on their cell surfaces.

Accepted Answer

A)  IgA
B)  IgD
C)  IgE
D)  IgG
E)  IgMF) B) and E)
G) A) and B)

Question 8

Transgenic animals that fail to express a BCR during the immature B-cell stages lose the capacity to produce any B cells at all.What does this observation indicate?

Accepted Answer

The observation indicates that...

Question 9

Mature B-2 or follicular B cells are most commonly found in the

Accepted Answer

A)  bone marrow.
B)  lymph node.
C)  marginal zones of the spleen.
D)  peritoneal.
E)  secondary lymphoid organs.F) A) and B)
G) A) and D)

Question 10

Which cell type is found in both B- and T-cell lineages?

Accepted Answer

A)  Common lymphoid progenitors
B)  Common pro-B-T cells
C)  Immature B cell
D)  Naïve lymphoid progenitor
E)  Pro-B-T cellF) B) and D)
G) A) and B)

Question 11

Recent experiments have focused on identifying differences between signal transduction events leading to B-cell activation versus B-cell anergy.As a new tutor for immunology, how would you summarize these recent experiments to a student client?

Accepted Answer

Anergic B cells show less antigen-induce...

Question 12

V-DJ recombination occurs during which phase of a B cell's development?

Accepted Answer

A)  Activated B cell
B)  Mature B cell
C)  Naïve B cell
D)  Pro-B cell
E)  Immature B cellF) A) and C)
G) B) and C)

Question 13

B lymphocytes are made in the

Accepted Answer

A)  blood stream.
B)  bone marrow.
C)  liver.
D)  thymus.
E)  totipotent cell.F) A) and E)
G) B) and D)

Question 14

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Accepted Answer

A)  Pre-pro-B cell
B)  Early pro-B cell
C)  Late pro-B cell
D)  Late pre-B cell
E)  Immature B cellF) B) and D)
G) B) and C)

Question 15

Immature B cells in the bone marrow that are found to bear self-antigen reactive BCRs undergo which of the following?

Accepted Answer

A)  Clonal deletion
B)  Light chain receptor editing
C)  Development of anergy
D)  All of the answers are correct.
E)  None of the answers are correct.F) A) and B)
G) B) and C)

Question 16

Which of the following statements regarding HSCs is/are TRUE?
I.HSCs are not self-renewing.
II.HSCs can make copies of themselves.
III.HSCs give rise to one cell lineage.
IV.HSCs are multipotent.
V.HSCs express both RAG1 and RAG2 surface markers.

Accepted Answer

A)  Statement I only
B)  Statements I and III only
C)  Statements II and III only
D)  Statements II and IV only
E)  Statements III and V onlyF) A) and E)
G) A) and B)

Question 17

At what site(s)  can mature HSCs be found by day 11 in the mouse model?

Accepted Answer

A)  AGM
B)  Fetal liver
C)  Placenta
D)  Yolk
E)  All of the answers are correct.F) B) and E)
G) B) and C)

Question 18

This type of cell will leave the bone marrow and complete maturation in the spleen.

Accepted Answer

A)  Common lymphoid progenitor cell
B)  Hematopoietic stem cell
C)  Immature B cell
D)  Pro-B cell
E)  Pro-T cellF) C) and E)
G) A) and E)

Question 19

The common lymphoid progenitor cell gives rise to all the following cell lines EXCEPT

Accepted Answer

A)  dendritic cells.
B)  megakaryocytes.
C)  natural killer cells.
D)  pre-pro B cells.
E)  T-cell progenitor.F) C) and D)
G) C) and E)

Question 20

Which molecule listed below appears to play a critical role in trafficking B cells from the bone marrow to the spleen to complete cellular maturation?

Accepted Answer

A)  SCF
B)  S1P
C)  IL-7
D)  BIM
E)  Both SCF and S1P are correct.F) A) and E)
G) A) and D)

Exam 9: B-Cell Development

The common lymphoid progenitor cell gives rise to all the following cell lines EXCEPT

Correct AnswerverifiedShow Answer

Which molecule listed below appears to play a critical role in trafficking B cells from the bone marrow to the spleen to complete cellular maturation?

Correct AnswerverifiedShow Answer

Mature B-2 or follicular B cells are most commonly found in the

Correct AnswerverifiedShow Answer

All of the following are true regarding B-cell development EXCEPT

Correct AnswerverifiedShow Answer

Transgenic animals that fail to express a BCR during the immature B-cell stages lose the capacity to produce any B cells at all.What does this observation indicate?

Correct AnswerverifiedThe observation indicates that...View AnswerShow Answer

Which of the following statements regarding HSCs is/are TRUE? I.HSCs are not self-renewing. II.HSCs can make copies of themselves. III.HSCs give rise to one cell lineage. IV.HSCs are multipotent. V.HSCs express both RAG1 and RAG2 surface markers.

Correct AnswerverifiedShow Answer

Recent experiments have focused on identifying differences between signal transduction events leading to B-cell activation versus B-cell anergy.As a new tutor for immunology, how would you summarize these recent experiments to a student client?

Correct AnswerverifiedAnergic B cells show less antigen-induce...View AnswerShow Answer

Hematopoiesis begins at around day 7 after fertilization in mice.What is the site of precursor cells at this stage of fetal development?

Correct AnswerverifiedShow Answer

Mature naïve B cells express high levels of _____ on their cell surfaces.

Correct AnswerverifiedShow Answer

Marginal-zone B cells express

Correct AnswerverifiedShow Answer

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Correct AnswerverifiedShow Answer

B lymphocytes are made in the

Correct AnswerverifiedShow Answer

Immature B cells in the bone marrow that are found to bear self-antigen reactive BCRs undergo which of the following?

Correct AnswerverifiedShow Answer

What is the initial location of B-cell and T-cell development?

Correct AnswerverifiedShow Answer

Which cell type is found in both B- and T-cell lineages?

Correct AnswerverifiedShow Answer

Individuals of retirement age or older show lower antibody mediate immune responses due to all the following reasons EXCEPT

Correct AnswerverifiedShow Answer

This type of cell will leave the bone marrow and complete maturation in the spleen.

Correct AnswerverifiedShow Answer

At what site(s) can mature HSCs be found by day 11 in the mouse model?

Correct AnswerverifiedShow Answer

V-DJ recombination occurs during which phase of a B cell's development?

Correct AnswerverifiedShow Answer

Of the cells listed below, which one represents the MOST developed B cell?

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
The observation indicates that...
View Answer

Correct Answer
verified

Correct Answer
verified
Anergic B cells show less antigen-induce...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful V_H-DJ_H combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified