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The diaphragm is a large sheet of smooth muscle that separates the thoracic cavity from the abdomen.

A) True
B) False

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During a yoga class you take a deep breath,then relax and let the breath out slowly.During that exhalation,which would NOT be true?


A) Alveolar pressure is greater than atmospheric pressure.
B) Intrapleural pressure is greater than alveolar pressure.
C) Intrapleural pressure becomes less negative.
D) The diaphragm relaxes.
E) Lung volume decreases.

F) A) and D)
G) All of the above

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Which of the following conditions would result in a systemic arterial PO₂ lower than is typical of a healthy person at sea level?


A) Traveling to high altitude
B) Breathing 100% oxygen
C) Having iron-deficiency anemia
D) Breathing regular air in a hyperbaric chamber (higher that normal atmospheric pressure)
E) Maintaining alveolar ventilation constant while decreasing metabolic rate

F) B) and C)
G) B) and D)

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One cause of hypoxic hypoxia in disease is diffusion impairment of O₂ resulting from decreased alveolar surface area.

A) True
B) False

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During a physical examination,Joe learns that his resting tidal volume is 550 mL;his average resting respiratory rate is 15 breaths per minute;his total lung capacity is 6,000 mL;and his anatomic dead space is 150 mL.Joe's resting alveolar ventilation is


A) 72.0 L/min.
B) 6.0 L/min.
C) 4.2 L/min.
D) 1.8 L/min.
E) 0.5 L/min.

F) B) and C)
G) All of the above

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In a normal person at rest,the part of the respiratory cycle in which no air is flowing through the airways and the respiratory muscles are relaxed is at the end of inhalation/inspiration,prior to exhalation/expiration.

A) True
B) False

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Regarding the relationships between the rates of oxygen consumption/carbon dioxide production and alveolar ventilation,which of these statements is TRUE?


A) Increased ventilation without a similar increase in metabolism is called hypoventilation.
B) In hypoventilation,alveolar PCO₂ decreases below resting levels.
C) In hyperventilation,alveolar PCO₂ can decrease to zero.
D) A decrease in metabolism without a similar decrease in alveolar ventilation would result in hyperventilation.
E) An increase in ventilation with a matching increase in metabolism is called hyperventilation.

F) A) and E)
G) A) and B)

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The total dead space in the lungs includes anatomic dead space and any portion of the alveoli that has little or no blood supply.

A) True
B) False

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The rhythmic contractions and relaxations of the inspiratory muscles are dependent upon spontaneous depolarizations of the diaphragm.

A) True
B) False

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After CO₂ is produced by tissues,in what form is most of that carbon transported to the lungs for removal from the body?


A) As dissolved CO₂
B) Bound to hemoglobin
C) As H₂CO₃
D) As dissolved HCO₃⁻
E) As carbonic anhydrase

F) A) and C)
G) All of the above

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Action potentials in neurons in the inspiratory center of the medulla oblongata result in action potentials in the ________ nerves to the diaphragm,which in turn cause ________ of the muscle,resulting in a/an ________ in the volume of the thoracic cage.


A) motor;contraction;decrease
B) parasympathetic;contraction;decrease
C) sympathetic;contraction;increase
D) motor;contraction;increase
E) sympathetic;relaxation;increase

F) A) and C)
G) C) and D)

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Carbonic anhydrase catalyzes a reaction that combines which of the following?


A) H₂O and O₂
B) H₂O and CO₂
C) H₂O and CO
D) H⁺ and HCO₃⁻
E) CO₂ and O₂

F) B) and E)
G) A) and B)

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You embark on a hiking trip on Mt.Kilimanjaro (altitude = 19,000 ft;Atmospheric air pressure = 379 mmHg) .mHg) .As you ascend,what are you likely to notice about your breathing?


A) You need to work to exhale,using your muscles to decrease your thoracic size beyond what is normal
B) You need to work harder to inhale,expanding your thoracic size beyond what is normal
C) Both would happen
D) Neither would happen

E) A) and C)
F) A) and B)

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You (a healthy individual) are swimming underwater when you can no longer resist the urge to breathe.This overwhelming urge is probably due to


A) the autorhymthic cells in your diaphragm contracting.
B) the decrease in O₂ available to the cells of the body.
C) the increase in plasma H⁺.
D) the increase in pH has made your blood dangerously alkaline.

E) C) and D)
F) B) and D)

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An individual with emphysema will have a lower tidal volume than an individual of the same size without emphysema.

A) True
B) False

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Drug X is a new drug to treat Alzheimer's Disease.This drug is able to cross the blood-brain barrier and circulate in the CSF.The drug is slightly acidic and at the recommended dose it decreases the CSF pH from 7.4 to 7.3.Will Drug X have any effect on respiration?


A) It will cause an increase in respiratory rate.
B) It will cause a decrease in respiratory rate.
C) It will have no effect on respiratory rate,but will cause an increase in depth of breathing.
D) It will have no effect on respiratory rate,but will cause the patient to take shallower breaths.
E) It will not impact respiratory function.

F) A) and E)
G) All of the above

Correct Answer

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Of the CO₂ returning from the tissues in venous blood,more is dissolved in plasma as CO₂ than is bound to hemoglobin.

A) True
B) False

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Which of these would tend to increase ventilation?


A) Lower than normal arterial PCO₂
B) Higher than normal arterial pH
C) Breathing carbon monoxide
D) Breathing air with increased PCO₂
E) Iron-deficiency anemia

F) D) and E)
G) A) and B)

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A clinical sign of obstructive lung disease would be a reduced FEV1/FVC ratio,where "FVC" is "forced" VC.

A) True
B) False

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Maria is a patient in the ward who was recently in a motor vehicle accident.Her injuries are causing her a lot of pain,and as a consequence to the morphine she's been given,her respiratory rate is quite low.Which of the following is likely to be TRUE?


A) The pH of her blood has increased.
B) The level of O₂ in her blood has increased.
C) The level of H⁺ ions in her blood has increased.
D) The alveolar CO₂ has decreased to near atmospheric levels.
E) The alveolar O₂ level has increased toward atmospheric levels.

F) A) and E)
G) A) and B)

Correct Answer

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