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The membrane attack stage of the complement cascade involves


A) initiation of the cascade.
B) production of inflammatory cytokines.
C) the assembly of a ring-shaped protein that forms holes in bacterial cell membranes and virus envelopes.
D) cleaving of C3 to yield C3a and C3b.
E) C1q binds to surface receptors on a membrane.

F) A) and C)
G) B) and D)

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All of the following are types of agranulocytes because they do not have prominent granules in their cytoplasm when stained, except


A) T-cells.
B) B-cells.
C) monocytes.
D) lymphocytes.
E) basophils.

F) A) and E)
G) A) and B)

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Neutrophils, eosinophils, and basophils are called _____ because they have prominent cytoplasmic granules that, in a stained blood smear, appear with identifying, characteristic colors.

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Which of the following is an example of GALT?


A) appendix
B) lymph nodes
C) spleen
D) tonsils
E) thymus gland

F) A) and B)
G) A) and E)

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Endotoxin is an exogenous pyrogen.

A) True
B) False

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Joan's inflamed and painful joints are likely due to which of the following chemicals?


A) gamma interferon
B) interleukin-5
C) prostaglandins
D) histamine
E) platelet-activating factor

F) None of the above
G) C) and E)

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During what process are hypochlorite and hydrogen peroxide produced to destroy bacteria and inhibit viral replication?


A) inflammation
B) phagocytosis
C) interferon production
D) complement production
E) lysozyme production

F) A) and B)
G) C) and D)

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Elimination and destruction systems present in the phagolysosome include all the following, except


A) bromine.
B) hydroxyl free radical.
C) nitric oxide.
D) lactic acid.
E) lysozyme.

F) A) and C)
G) All of the above

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Histamine, serotonin, and bradykinin are all


A) vasoactive mediators.
B) mediators of B-cell activity.
C) mediators of T-cell activity.
D) mediators that increase chemotaxis.
E) fever inducers.

F) B) and D)
G) D) and E)

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The most numerous WBCs, that have multilobed nuclei and are very phagocytic are


A) basophils.
B) eosinophils.
C) neutrophils.
D) monocytes.
E) lymphocytes.

F) C) and D)
G) A) and E)

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Certain complement components stimulate inflammation and phagocytosis.

A) True
B) False

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Hemopoiesis is the


A) loss of blood due to hemorrhaging.
B) production of only red blood cells.
C) production of white blood cells, red blood cells, and platelets.
D) plugging of broken vessels to stop bleeding.
E) migration of white blood cells from the blood out to the tissues.

F) C) and D)
G) B) and D)

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All of the following are correct about lymph, except


A) its composition is similar to plasma.
B) it travels in vessels similar to blood vessels.
C) it is made mostly of water.
D) it transports numerous white blood cells.
E) it is transported through the body by the same pump as blood, i.e., the heart.

F) C) and D)
G) All of the above

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The clearance of pus, cellular debris, dead neutrophils, and damaged tissue after inflammation is performed by


A) basophils.
B) eosinophils.
C) neutrophils.
D) macrophages.
E) lymphocytes.

F) A) and D)
G) D) and E)

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Dermacidin is an antimicrobic peptide secreted by skin cells, which breaks down bacterial membranes and causes them to lyse.

A) True
B) False

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The key phagocytic cells of the body are the


A) neutrophils and macrophages.
B) basophils and neutrophils.
C) eosinophils and macrophages.
D) macrophages and monocytes.
E) natural killer cells.

F) All of the above
G) A) and B)

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_____ lymphocytes function in humoral immunity, while _____ lymphocytes function in cell-mediated immunity.

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Components of the first line of defense include all the following, except


A) the tough cell sheet of the upper epidermis of the skin.
B) nasal hairs.
C) flushing action of tears and blinking.
D) flushing action of urine.
E) phagocytic white blood cells.

F) A) and D)
G) B) and E)

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When monocytes migrate from the blood out to the tissues, they are transformed by inflammatory mediators to develop into _____.

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Which is mismatched?


A) interferon alpha and beta - inhibits viral replication
B) interleukin-2 - stimulates T-cell mitosis and B-cell antibody production
C) serotonin - causes smooth muscle contraction
D) prostaglandins - activate eosinophils and B-cells
E) tumor necrosis factor - increases chemotaxis and phagocytosis

F) A) and B)
G) A) and C)

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