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The drug chloral hydrate prevents elongation of microtubules by preventing the addition of new subunits to the growing end. During which stage of mitosis would chloral hydrate be most harmful?


A) prophase
B) metaphase
C) anaphase
D) telophase
E) interphase

F) C) and E)
G) A) and D)

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What is the structure that holds together the two sister chromatids that form a chromosome?


A) centromere
B) nucleosome
C) histone
D) nucleus
E) chromatin

F) None of the above
G) A) and B)

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Which of the following is not a characteristic of cancer cells?


A) cells that have lost contact inhibition
B) cells with abnormal nuclei
C) cells that spend 90% of their lifetime in interphase
D) cells that lack differentiation
E) cells that have uncontrolled cell division

F) C) and D)
G) A) and E)

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Susan went to an oncologist because some cancerous cells had been detected within her breast tissue. Which of the following is not a warning signal for cancer?


A) The cells in the breast tissue lacked differentiation.
B) Some cells in the tissue had failed to acquire the specialized structure that the cell should have.
C) Some cells had abnormally large nuclei.
D) The cells had an abnormal number of chromosomes.
E) Some cells were found to be in interphase.

F) A) and B)
G) A) and C)

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The structure labeled "c" in the following figure is called the The structure labeled  c  in the following figure is called the   A)  centromere. B)  centriole. C)  sister chromatid. D)  spindle. E)  non-sister chromatid.


A) centromere.
B) centriole.
C) sister chromatid.
D) spindle.
E) non-sister chromatid.

F) C) and D)
G) C) and E)

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A protein that promotes apoptosis would be considered an)


A) oncogene.
B) proto-oncogene.
C) tumor suppressor.
D) mutant tumor suppressor.
E) signal transduction pathway protein.

F) A) and E)
G) None of the above

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What would occur in a cell if the production of cyclins halted during the cell cycle?


A) DNA would not be replicated in the S phase.
B) Organelles would not be duplicated in G1.
C) The cell would not complete cytokinesis.
D) The cell would enter the G0 phase.
E) The cell would remain in the G2 phase and would not enter into mitosis.

F) D) and E)
G) A) and B)

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The mitotic spindle is composed of ________ and grows from the ________ toward the center of the cell.


A) microtubules; centrosome
B) asters; spindle equator
C) centrosomes; aster
D) microtubules; chromatid
E) microtubules; cleavage furrow

F) B) and E)
G) B) and D)

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Which of the following statements is correct regarding the events of the cell cycle?


A) DNA is duplicated during the G1 and G2 phases.
B) DNA replicates during cytokinesis.
C) The M phase is usually the longest phase.
D) Interphase consists of G1, S, and G2.
E) The cell stops growing in G2 phase.

F) A) and E)
G) C) and D)

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If a cell has 46 chromosomes at the beginning of mitosis, then at the end of anaphase there would be a total of


A) 23 chromatids.
B) 23 chromosomes.
C) 46 chromatids.
D) 46 chromosomes.
E) 92 chromosomes.

F) B) and D)
G) All of the above

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A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 picograms of DNA in the nucleus. Those cells would have ________ picograms at the end of the S phase and ________ picograms at the end of G2.


A) 8; 8
B) 8; 16
C) 16; 8
D) 16; 16
E) 12; 16

F) A) and B)
G) B) and D)

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Plant cells and animal cells differ in cytokinesis because


A) plant cells need to build a cell wall, while animal cells do not.
B) plant cells need to build a cell wall, while animal cells built the extra cellular matrix.
C) animal cells need to build a cell membrane, while plant cells do not.
D) animal cells are living, while plant cells are not.
E) plant cells divide by mitosis, while animal cells divide by meiosis.

F) A) and B)
G) None of the above

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Translocations can lead to cancer if they disrupt the genes that regulate the cell cycle.

A) True
B) False

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Proteins that are involved in the regulation of the cell cycle, and that show fluctuation in concentration during the cell cycle, are called


A) centromeres.
B) kinetochores.
C) centrioles.
D) proton pumps.
E) cyclins.

F) None of the above
G) C) and D)

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The figure below shows a cell in the mitotic stage of The figure below shows a cell in the mitotic stage of   A)  anaphase. B)  interphase. C)  metaphase. D)  prophase. E)  telophase.


A) anaphase.
B) interphase.
C) metaphase.
D) prophase.
E) telophase.

F) A) and E)
G) C) and E)

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Losing weight can reduce an obese person's risk for cancer by up to 40%.

A) True
B) False

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A mutation results in a cell that no longer produces a normal protein kinase for the M-phase checkpoint. Which of the following would likely be the immediate result of this mutation?


A) The cell would prematurely enter anaphase.
B) The cell would never leave metaphase.
C) The cell would never enter metaphase.
D) The cell would never enter prophase.
E) The cell would undergo normal mitosis, but fail to enter the next G1.

F) A) and D)
G) All of the above

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The looping of DNA around histone proteins


A) produces the characteristic helix shape of the DNA.
B) allows the room for cellular machinery to reach all genes so they may be transcribed.
C) condenses a large amount of DNA so that it can fit into the cell.
D) prevents the DNA from becoming kinked and breaking.
E) occurs when the DNA is damaged and allows the cell to be destroyed through apoptosis.

F) All of the above
G) B) and E)

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